MEPSEVII® (vestronidase alfa-vjbk) should be administered under the supervision of a health care professional with the capability to manage anaphylaxis
MEPSEVII recommended dosage overview
- Approximately 4-hour intravenous drip
- Administer by intravenous infusion every 2 weeks
- Infuse 2.5% of the total volume over the first hour
- After the first hour, increase the infusion rate as tolerated in order to complete infusion over the following 3 hours
- Premedication with a nonsedating antihistamine with or without an antipyretic is recommended 30 to 60 minutes prior to the start of infusion, for patient comfort
Supplies needed
- MEPSEVII (vestronidase alfa-vjbk) 10-mg/5-mL single-dose vials
- 0.9% Sodium Chloride Injection, USP
- Infusion bag
- 18-gauge needle
- An infusion set equipped with an in-line, low-protein binding 0.2-micron filter
MEPSEVII® (vestronidase alfa-vjbk) should be administered under the supervision of a health care professional with the capability to manage anaphylaxis
MEPSEVII recommended dosage overview
-
Approximately 4-hour intravenous drip
-
Administer by intravenous infusion every 2 weeks
-
Infuse 2.5% of the total volume over the first hour
-
After the first hour, increase the infusion rate as tolerated in order to complete infusion over the following 3 hours
-
Premedication with a nonsedating antihistamine with or without an antipyretic is recommended 30 to 60 minutes prior to the start of infusion, for patient comfort
Supplies needed
- MEPSEVII (vestronidase alfa-vjbk) 10-mg/5-mL single-dose vials
- 0.9% Sodium Chloride Injection, USP
- Infusion bag
- 18-gauge needle
- An infusion set equipped with an in-line, low-protein binding 0.2-micron filter
Calculating the dose
- Weigh the patient to determine the number of vials to be diluted based on the patient’s actual weight and the recommended dose of 4 mg/kg
- Round to the next whole vial to determine the final total volume and number of vials needed based on the patient's weight
- The final solution will be a 1:1 dilution of MEPSEVII with 0.9% Sodium Chloride Injection, USP
Calculating the dose
- Weigh the patient to determine the number of vials to be diluted based on the patient’s actual weight and the recommended dose of 4 mg/kg
- Round to the next whole vial to determine the final total volume and number of vials needed based on the patient's weight
- The final solution will be a 1:1 dilution of MEPSEVII with 0.9% Sodium Chloride Injection, USP