Administration instructions

The diluted MEPSEVII solution is administered to patients using an infusion set equipped with an in-line, low-protein binding 0.2-micron filter.

MEPSEVII should be administered under the supervision of a health care professional with the capability to manage anaphylaxis.

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  1. The rate of infusion: In the first hour, infuse 2.5% of the total volume, and infuse the remaining volume over the subsequent 3 hours. Account for any dead space in the lines to ensure 2.5% of the total infusion volume is delivered into the patient’s bloodstream during the first hour of infusion.
  2. Use an infusion set equipped with an in-line, low-protein binding 0.2 micron filter to administer the diluted MEPSEVII solution.
  3. Do not flush the line containing MEPSEVII to avoid a rapid bolus of infused enzyme. Due to the low infusion rate, additional saline may be added through a separate line (piggyback or Y tube) to maintain sufficient intravenous flow to prevent clotting or line blockage.
  4. Do not infuse with other products in the infusion tubing. Compatibility with other products has not been evaluated.
  5. Use MEPSEVII immediately after dilution and complete the infusion within 42 hours from the time of dilution. Discard any unused product.
Image
  1. The rate of infusion: In the first hour infuse 2.5% of the total volume, and infuse the remaining volume over the subsequent 3 hours. Account for any dead space in the lines to ensure 2.5% of the total infusion volume is delivered into the patient’s bloodstream during the first hour of infusion.
  2. Use an infusion set equipped with an in-line, low-protein binding 0.2 micron filter to administer the diluted MEPSEVII solution.
  3. Do not flush the line containing MEPSEVII to avoid a rapid bolus of infused enzyme. Due to the low infusion rate, additional saline may be added through a separate line (piggyback or Y tube) to maintain sufficient intravenous flow to prevent clotting or line blockage.
  4. Do not infuse with other products in the infusion tubing. Compatibility with other products has not been evaluated.
  5. Use MEPSEVII immediately after dilution and complete the infusion within 44 hours from the time of dilution. Discard any unused product.